Padhy, JagamohanSamal, Pradeep KumarChoudhary, RajeshShree, JayaVaishnaw, Bharti2024-09-242024-09-242024-09-242024-09-242024-02Padhy Jagamohan, Samal Pradeep Kumar, Choudhary Rajesh, Shree Jaya, Vaishnaw Bharti . Combined Antidepressant Effect of Acetyl-L-Carnitine and Bupropion against Experimental Animal Model . International Journal of Pharmaceutical Sciences and Drug Research . 2024 Jan; 16(1): 16-210975–248Xhttps://imsear.searo.who.int/handle/123456789/231748Depression is one of the most common mental diseases characterized by mood disorders affecting around 322 million individuals in the world. Depression is a feeling of inadequacy, dejection, anhedonia, and decreased activity in any action. Previously acetyl-L-carnitine reported beneficial effects on lipid metabolism, neuroprotection, and some types of depression. Therefore, in the present study, we evaluated the combined effect of acetyl-L-carnitine and bupropion against experimental-induced depression. Albino rats were divided into different groups (each group contained six animals). Normal groups received saline (1 mL/kg, i.p.). The standard group received imipramine (20 mg/kg, i.p.). The ALC group received acetyl-L-carnitine (100 mg/kg, i.p.), and the BPR group received bupropion (20 mg/kg, i.p.). T I and T II groups received acetyl-L-carnitine (30 mg/kg, i.p.) + Bupropion (10 mg/kg, i.p.) and acetyl-L-carnitine (80 mg/kg, i.p.) + Bupropion (30 mg/kg, i.p.), respectively. Antidepressant effects were assessed by forced swim test and sucrose preference test. In both models, the combined effect of the drug produced a significant (p < 0.05) antidepressant action as compared to the depression control group. Based on the findings, the combined effect of acetyl-L-carnitine and bupropion had a better therapeutic effect to combat depression as compared to individual treatments.DepressionAcetyl L carnitineBupropionForced swim testSucrose preference testJournal ArticleIndiaDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, IndiaDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, IndiaDepartment of Pharmacology, Shri Shankaracharya College of Pharmaceutical Sciences, Shri Shankaracharya Professional University, Bhilai, Chhattisgarh, IndiaDepartment of Pharmacology, Shri Shankaracharya College of Pharmaceutical Sciences, Shri Shankaracharya Professional University, Bhilai, Chhattisgarh, IndiaDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India