Sardoğan, SeyfiŞanlı, SenemSardoğan, BarışAtalay, Barış2020-11-182020-11-182020-08Sardoğan Seyfi, Şanlı Senem, Sardoğan Barış, Atalay Barış. Residue Analysis of Oxytetracycline in Milk Sample by Two Different Chromatographic Methods and Determination of Ionization Constant Values. Journal of Pharmaceutical Research International. 2020 Aug; 32(15): 1-92456-91192231-2919http://imsear.searo.who.int/handle/123456789/215868In thepresent study, two analytical methods for the residue analysis of oxytetracycline in milk sample have been generated. InHPLC method, the analysis was performed on an X Terra RP-18 column at 25 °C with the mobile phase as methanol: water (20 : 80 )(v/v) modified to pH 5. For the second method capillary electrophoresis system was used. The analysis of oxytetracycline in milk sample could be achieved without using organic modifier in a 58 cm length capillary at a working voltage of 12 kV with 20 mM NaH2PO4-H3PO4(pH 7) by capillary electrophoresis. Tetracycline was used as internal standard in both methods. The results calculatedfrom both methods were compared to each other. The calculated data for drugs was checked with the data predicted by the SPARC on-line pKa estimatorOxytetracyclinemilkresidue analysisHPLCcapillary electrophoresisJournal ArticleIndiaDepartment of Food Engineering, Faculty of Engineering, Uşak University, Uşak, TurkeyDepartment of Chemistry, Faculty of Science and Arts, Uşak University, Uşak, TurkeyDepartment of Medical Laboratory Techniques, Vocational School of Health Services, Uşak University, Uşak, TurkeyDepartment of Rectorate, Uşak University, Uşak, Turkeyİzmir Kavram Vocational College of Higher Education, İzmir, Turkey