Gupta, SGupta, Y KSharma, S S2007-01-202009-06-012007-01-202009-06-012007-01-20Gupta S, Gupta YK, Sharma SS. Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils. Indian Journal of Physiology and Pharmacology. 2007 Jan-Mar; 51(1): 62-8http://imsear.searo.who.int/handle/123456789/108006Involvement of p53 has been implicated in apoptosis induced cell death in ischemic reperfusion injury. In the present study, we have investigated neuroprotective potential of pifithrin-alpha, a p53 inhibitor in bilateral common carotid arteries occlusion (5 min) model of global cerebral ischemia in Mongolian gerbils. Gerbils were treated with pifithrin-alpha 3 mg/kg, ip. 30 min prior to occlusion. There was a significant increase in neurological symptoms and locomotor activity in ischemic animals as compared with the sham-operated animals. Increase in neurological symptoms and locomotor activity was attenuated by pifithrin-alpha 3 mg/ kg, ip. Significant increase in the number of the surviving neurons in the hippocampal CA1 pyramidal region was observed in ischemic animals treated with pifithrin-alpha 3 mg/kg, ip. This study demonstrates the neuroprotective effect of pifithrin-alpha in global cerebral ischemia in gerbils.engAnimalsArterial Occlusive Diseases --complicationsBenzothiazoles --administration & dosageBrain Ischemia --etiologyCarotid Artery Diseases --complicationsCell Death --drug effectsCell Survival --drug effectsGerbillinaeHippocampus --drug effectsInjections, IntraperitonealMaleMotor Activity --drug effectsNeuroprotective Agents --administration & dosagePyramidal Cells --drug effectsReperfusion Injury --etiologyTime FactorsToluene --administration & dosageJournal Article