Kulkarni, V MMishra, D S1985-10-012009-05-281985-10-012009-05-281985-10-01Kulkarni VM, Mishra DS. Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone. Indian Journal of Leprosy. 1985 Oct-Dec; 57(4): 756-62http://imsear.searo.who.int/handle/123456789/54806Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.engAnimalsDapsone --administration & dosageDrug Evaluation, PreclinicalLeprosy --drug therapyRabbitsJournal Article