Dhuley, Jayant N2002-02-062009-05-272002-02-062009-05-272002-02-06Dhuley JN. Hepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats. Hindustan Antibiotics Bulletin. 2002 Feb-Nov; 44(1-4): 53-9http://imsear.searo.who.int/handle/123456789/2339Rhinax, a polyherbal formulation, exhibited hepatoprotective function when tested against antitubercular drug-induced hepatotoxicity in rats. Suppression of GSH and antioxidant enzymes "superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), gultathionle peroxidase (GPx) and glutathione S-transferase (GST) were noticed in the liver of antitubercular chemotherapeutic agents (namely isoniazid, rifampicin and pyrazinamide) treated animals accompanied with an increase in cytochrome P-450 contents and increased production of lipid peroxidation. Rhinax afforded hepatoprotection by inhibiting lipid peroxidation and, as a result, the animals showed improved antioxidant status.engAnimalsAntitubercular Agents --toxicityHepatitis, Toxic --enzymologyHerbal MedicineLipid Peroxidation --drug effectsLiver --enzymologyLiver Function TestsMaleMedicine, AyurvedicPlant Extracts --therapeutic useRatsRats, WistarJournal Article