Samuel, JThomas, KJeyaseelan, LPeter, J VCherian, A M1995-05-012009-05-301995-05-012009-05-301995-05-01Samuel J, Thomas K, Jeyaseelan L, Peter JV, Cherian AM. Incidence of intermediate syndrome in organophosphorous poisoning. Journal of the Association of Physicians of India. 1995 May; 43(5): 321-3http://imsear.searo.who.int/handle/123456789/90713Seventy two patients admitted to the Intensive Care Unit following ingestion of organophosphorus compounds were studied prospectively with two different doses of pralidoxime (PAM). One group received 1 gm immediately after admission and no further PAM and the other group received infusion of PAM, 1 gm 8 hourly for four days (total 12 gms). The incidence of type II paralysis or intermediate syndrome was 47%. We observed a higher incidence in the 4 days of infusion of PAM group (61%) (20 patients) as compared to the single Bolus dose group (39%) (13 patients). Relative risk 1.48 (confidence interval = 0.9-2.4).engAdultCholinesterase Reactivators --administration & dosageDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleHumansInfusions, IntravenousMaleOrganophosphorus Compounds --poisoningOverdose --drug therapyParalysis --chemically inducedPralidoxime Compounds --administration & dosageProspective StudiesRespiratory Paralysis --chemically inducedSyndromeClinical Trial