Chowdhury, ASantra, AKundu, SMukherjee, APandit, AChaudhuri, SDhali, G K2001-05-132009-05-292001-05-132009-05-292001-05-13Chowdhury A, Santra A, Kundu S, Mukherjee A, Pandit A, Chaudhuri S, Dhali GK. Induction of oxidative stress in antitubercular drug-induced hepatotoxicity. Indian Journal of Gastroenterology. 2001 May-Jun; 20(3): 97-100http://imsear.searo.who.int/handle/123456789/65412BACKGROUND AND AIM: Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers. METHODS: This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured. RESULTS: Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls. CONCLUSION: Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.engAdultAgedAntitubercular Agents --adverse effectsCase-Control StudiesFemaleGlutathione --bloodHepatitis, Toxic --bloodHumansLinear ModelsLiver Function TestsMaleMalondialdehyde --bloodMiddle AgedOxidative StressProspective StudiesStatistics, NonparametricTuberculosis --drug therapyJournal Article