Mathur, S KMukherjee, S K2009-05-282009-05-281990-02-01Mathur SK, Mukherjee SK. Potassium induced insulin release from isolated islet of Langerhans of albino rats. Indian Journal of Experimental Biology. 1990 Feb; 28(2): 187-8http://imsear.searo.who.int/handle/123456789/63301The secretory effect of Potassium (K+) on endocrine pancreas was studied using collagenase digested isolated islets of Langerhans. Isolated islets of Langerhans incubated in KRB containing 5 15, 30 and 45 mM, quantity of additional K ions caused the release of insulin from beta-cells (significant release of insulin, P less than 0.01, at 15, 30 and 45 mM K+ in presence of 2.8 mM glucose and at 30 mM K in presence of 16.7 mM glucose). But lysosomal AP and CB enzymes did not record proportionate change. Thus a definite stimulation in the release of insulin without significant change in AP and CB were seen.engAnimalsInsulin --secretionIslets of Langerhans --drug effectsMalePotassium --pharmacologyRatsJournal Article