Gupta, GauravMore, Amar SunilKumari, Rashmi RekhaLingaraju, Madhu CholenahalliKumar, DhirendraKumar, DineshMishra, Santosh KumarTandan, Surender Kumar2014-04-292014-04-292014-03Gupta Gaurav, More Amar Sunil, Kumari Rashmi Rekha, Lingaraju Madhu Cholenahalli, Kumar Dhirendra, Kumar Dinesh, Mishra Santosh Kumar, Tandan Surender Kumar. Protective effect of alcoholic extract of Entada pursaetha DC. against CCl4-induced hepatotoxicity in rats. Indian Journal of Experimental Biology. 2014 Mar; 52(3): 207-214.http://imsear.searo.who.int/handle/123456789/150350The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and total bilirubin, lactate dehydrogenase; by lowering hepatic levels of malonaldehyde, nitrate-nitrite, myeloperoxidase activity; enhancing activities of antioxidant enzymes, superoxide dismutase, catalase and increasing reduced glutathione levels in liver, which suggests the antioxidant property of PSE. Histopathological studies also supported the above biochemical parameters. The results suggested that alcoholic extract of E. pursaetha possesses significant hepatoprotective activity in CCl4-induced acute hepatotoxicity in rats and this is likely to be mediated through its antioxidant activities.enAntioxidantCCl4Entada pursaethaHepatoprotection Liver toxicityAnimalsAntioxidants --metabolismCarbon Tetrachloride --toxicityCatalase --metabolismDrug-Induced Liver Injury --drug therapyDrug-Induced Liver Injury --pathologyFabaceae --chemistryGlutathione --metabolismLipid Peroxidation --drug effectsLiver --drug effectsLiver --pathologyPlant Extracts --administration & dosagePlant Extracts --chemistryRatsSuperoxide Dismutase --metabolismArticle