Capoor, Malini RNair, DeepthiHasan, Azra SAggarwal, PushpaGupta, B2009-05-272009-05-272006-11-06Capoor MR, Nair D, Hasan AS, Aggarwal P, Gupta B. Typhoid fever: narrowing therapeutic options in India. The Southeast Asian Journal of Tropical Medicine and Public Health. 2006 Nov; 37(6): 1170-4http://imsear.searo.who.int/handle/123456789/34577The Southeast Asian Journal of Tropical Medicine and Public Health.Typhoid fever remains an important public health problem in India. One thousand four hundred fifty-eight blood cultures were screened, 178 grew out Salmonella enterica serovar Typhi. On agar dilution minimum inhibitory concentration (MIC) testing, 0.6% of the isolates were resistant to ciprofloxacin, 2% to cefotaxime and 1% to cefepime. Nalidixic acid resistance was observed in 51% isolates, of which 98.9% had decreased susceptibility (MIC > or = 0.125-4 microg/ml) to ciprofloxacin. One strain of nalidixic acid sensitive S. Typhi (NASST) also had a decreased MIC (0.125 microg/ml) to ciprofloxacin. Resistance to third and fourth generation cephalosporins is emerging in India and will gain significance in the coming decade. The molecular basis of resistance to cephalosporinsand ciprofloxacin resistance in NASST strains need to be further evaluated for S. Typhi.engAdultAnti-Infective Agents --administration & dosageColony Count, MicrobialDrug Resistance, BacterialDrug Resistance, Multiple, BacterialFemaleHumansIndiaMaleSalmonella typhi --drug effectsTyphoid Fever --diagnosisJournal Article