Supkamonseni, NattaponThinkratok, AreeMeksuriyen, DuangdeunSrisawat, Rungrudee2014-12-122014-12-122014-10Supkamonseni Nattapon, Thinkratok Aree, Meksuriyen Duangdeun, Srisawat Rungrudee. Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo. Indian Journal of Experimental Biology. 2014 Oct; 52(10): 965-971.http://imsear.searo.who.int/handle/123456789/153789In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. α-Amylase inhibitory activities of C. asiatica extract and rutin were significantly lower than acarbose, an anti-diabetic drug. Inhibition of α-glucosidase activity by C. asiatica extract, rutin, and acarbose was not different. The in vivo study substantiated the in vitro results. C. asiatica extract (1000 and 2000 mg/4 mL/kg), rutin (1000 mg/4 mL/kg), and orlistat (45 mg/4 mL/kg) significantly decreased plasma glucose, triglyceride and total cholesterol levels in lipid emulsion-induced hyperlipidemic rats at 3 h. However, plasma aspartate aminotransferase and alanine aminotransferase levels did not show significant change. The present work further supports that the C. asiatica extract and its bioactive rutin may help managing hypolipidemic and hypoglycemic effects.enAcarboseCentella asiaticaHypoglycemiaHypolipidemiaLipid emulsion-fed ratObesityOrlistatRutinAmylases --antagonists & inhibitorsAnalysis of VarianceAnimalsBlood Glucose --drug effectsCentella --chemistryGlycoside Hydrolase Inhibitors --chemistryGlycoside Hydrolase Inhibitors --pharmacologyHypoglycemic Agents --chemistryHypoglycemic Agents --pharmacologyHypolipidemic Agents --chemistryHypolipidemic Agents --pharmacologyLipase --antagonists & inhibitorsMalePlant Extracts --chemistryPlant Extracts --pharmacologyRatsRats, Wistaralpha-Glucosidases --metabolismArticle