Rajak, Bhupendra KumarGupta, Munesh KumarMishra, J.K.Thiru, Anbarasan2019-12-022019-12-022019-03Rajak Bhupendra Kumar, Gupta Munesh Kumar, Mishra J.K., Thiru Anbarasan. The clinical utility of Adenosine Deaminase (ADA) levels for the differentiation of tubercular and non-tubercular pleural effusion. Indian Journal of Preventive & Social Medicine. 2019 Mar; 50(1): 12-170301-1216http://imsear.searo.who.int/handle/123456789/186138Background: Extra pulmonary TB accounts for 15% of all TB cases. Its incidence is much higher about 50% in HIV positive patients. Tuberculous pleurisy is present in around 4% of all TB cases2. Tuberculosis is always the leading etiology of pleural effusions in the developing countries3. Aims and Objectives: We have lot of investigations to diagnose pulmonary tuberculosis like sputum AFB, CBNAAT, LPA. These tests have some limitations in pleural fluid. So we are in need of a better test for diagnosis of tuberculous pleural effusion especially in high burden countries like India. Methods: In this study we have evaluated the usefulness of ADA level in pleural fluid for diagnosis of tuberculous pleural effusion. This study conducted from May 2017 to June 2018. Conclusion: This is a case control study done in a tertiary care center in Varanasi included 100 cases (Tuberculous pleural effusion) and 100 controls (Non Tuberculous pleural effusion).TuberculosisAdenosine DeaminasePleural effusionJournal ArticleIndiaJunior Resident, Dept. of TB & Respiratory Diseases, IMS, BHUAsst. Prof., Dept of Microbiology, IMS, BHUProf., Dept. of TB & Respiratory Diseases, IMS, BHUJunior Resident, Dept. of TB & Respiratory Diseases, IMS, BHU