Kaur, AmandeepSingh, RanvirDey, Chinmoy SankarSharma, Shyam SundarBhutani, Kamlesh KSingh, Inder Pal2013-02-072013-02-072010-03Kaur Amandeep, Singh Ranvir, Dey Chinmoy Sankar, Sharma Shyam Sundar, Bhutani Kamlesh K, Singh Inder Pal. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd. Indian Journal of Experimental Biology. 2010 Mar; 48(3): 314-317.http://imsear.searo.who.int/handle/123456789/144974Hexane, chloroform and ethyl acetate extracts (100 µg/ml) of Alpinia galanga rhizomes exhibited significant activity in vitro against promastigotes of L. donovani. Twelve compounds namely, methyleugenol (1), p-coumaryl diacetate (2), 1'-acetoxychavicol acetate (3), 1'-acetoxyeugenol acetate (4), trans-p-acetoxycinnamyl alcohol (5), trans-3,4-dimethoxycinnamyl alcohol (6), p-hydroxybenzaldehyde (7), p-hydroxycinnamaldehyde (8), trans-p-coumaryl alcohol (9), galangin (10), trans-p-coumaric acid (11) and galanganol B (12) were isolated from these extracts. Of these, compounds 2, 3, 4 and 5 were found most active in vitro against promastigotes of L. donovani with IC50 values of 39.3, 32.9, 18.9 and 79.9 µM respectively. This is the first report of antileishmanial activity of the extracts and isolated constituents of A. galanga.enAlpinia galangaLeishmania donovaniLeishmaniasisPhenylpropanoidsPromastigotesArticle