Durga, RSridhar, PPolasa, H1992-04-012009-05-271992-04-012009-05-271992-04-01Durga R, Sridhar P, Polasa H. Antimutagenic activity of plumbagin in Ames Salmonella typhimurium test. Indian Journal of Medical Research. 1992 Apr; 96(): 143-5http://imsear.searo.who.int/handle/123456789/20554This paper reports the antimutagenic activity of plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone) against certain known chemical mutagens in a standard mutagenicity test system of Ames using S. typhimurium strains. Plumbagin by itself did not show any mutagenic effect, whereas it reduced significantly the mutagenic effect of 4-nitrophenylene diammine, phenyl hydrazine and sodium azide in test strains of S. typhimurium, suggesting that plumbagin possessed antimutagenic activity.engAzides --antagonists & inhibitorsHumansIndicators and ReagentsMutagenesis --drug effectsMutagenicity TestsNaphthoquinones --pharmacologyPhenylhydrazines --antagonists & inhibitorsSalmonella typhimuriumSodium AzideJournal Article