JAYARATNE, SA2011-02-142011-02-1420052005JAYARATNE, SA, Effect of chromium supplementation on glycemic status and serum lipid concentrations in type 2 diabetes mellitus , University of Sri Jayawardenepura USJ(MED), 2005: xiv,126[xiii]p.http://imsear.searo.who.int/handle/123456789/129766Dissertation: M.Phil., University of Sri Jayawardenepura: USJ(MED), 2005.Background: Chromium is a micronutrient, considered to be essential for birnak carbohydrate and lipid metabolism. Several studies have demonstrated the beneficial effect if chromium on the glycemic status and lipid profile of type 2 diabetes mellitus. Objective: To study the effect of chromium supplementation on glycemic status and serum lipid concentrations in type 2 diabetes mellitus. Method: Sixty type 2 diabetic patients were randomly assigned to two groups. A double blind technique was used and the patients received either 250æg of chromium picolinate or placebo for 12 weeks. The fasting blood glucose, glycated haemoglobin, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triacylglycerol concentrations were measured at baseline and 2,4,6,8,10 and 12 weeks after initiation of treatment. Serum insulin concentration was also measured at baseline and 12 weeks after initiation of treatment. Results: The fasting blood glucose, glycated haemoglobin, total cholesterol, low density lipoprotein cholesterol and triacylglycerol concentrations did not show a significant difference between the two groups during or at the end of the trial. High density lipoprotein cholesterol is the only parameter that showed a significant increase in concentration starting at 8 weeks after the initiation of treatment, and this trend continued until the end of 12 weeks (p=0.005). Serum insulin resistance calculated from the insulin concentration also did not show a significant difference between the two groups. Conclusion: Results of the trial shows a statistically significant improvement in the high density lipoprotein cholesterol concentration of the supplemented group when compared with the baseline value (p=0.0005). But parallel comparison of the high density lipoprotein cholesterol concentration of the two groups at the 4th, 8th, and 12th week did not show a significant difference. Supplementation of chromium had no effect on the glycemic status and the other lipid parameters.en-USUniversity of Sri Jayawardenepura, USJ(MED): Sri Lanka HELLIS NetworkDiabetes mellitusDiabetes Mellitus, Type 2Diabetes Mellitus, Type 2-bloodDiabetes Mellitus, Type 2-diet therapyLipids-bloodChromium-pharmacologyChromium-therapeutic useThesis