Mohammed Amged, AmeenSalman Taha Ahmed, ElmukashfiMohammed Abdalsalam, Ahmed AliHisham Nour, Aldayem AltayebHusham M taha, aloobAmira. H., Arman2025-08-132025-08-132025-01Mohammed Amged Ameen, Salman Taha Ahmed Elmukashfi, Mohammed Abdalsalam Ahmed Ali, Hisham Nour Aldayem Altayeb, Husham M taha aloob, Amira. H. Arman.. Association between Helicobacter pylori Infection and Iron Deficiency in Sudanese Population in Khartoum State. International Journal of TROPICAL DISEASE & Health. 2025 Jan; 46(1): 54-612278-1005https://imsear.searo.who.int/handle/123456789/251279Background: Helicobacter pylori infection is a major gastric infection worldwide and has been associated with many gastrointestinal and non-gastrointestinal diseases including hematological disorders. Objective: Aimed to study the association between H. pylori infection and iron deficiency among Sudanese population. Materials and Methods: This is analytical case control study, conducted in Sudan, Khartoum state in Omdurman locality, during the period from May 2018 to April 2019. Include 100 samples, the stool and blood samples were collected from 100 Sudanese subjects (50 were infected with H. pylori as cases and 50 were apparently healthy subjects as controls). Stool samples were tested for H. pylori Ag by commercially available kits (HanzouAllTest Biotech Co., Ltd, Germany), all blood samples were analyzed for complete blood count using (SYSMEX KX21N) automated analyzer and serum iron profile (iron, ferritin, and TIBC) using spectrophotometery and turbidimetry. The obtained results is analyzed by SPSS versions 16.0, significant level was set at p-value equal or less than 0.05 and the results were presented in form of tables and figures. Results: The results of H. pylori antigen were positive in all cases and negative in control samples. Serum iron level mean was significantly lower among H. pylori positive patient (62±18.1) than control group (91.3±16.7) (p-value 0.001), serum ferritin level mean was significantly lower in H. pylori infected patients (36.8±16.5) than control group (64±16.4) (p-value 0.003), hemoglobin level mean was significantly lower in H. pylori patients (12.5 ±1.1) than control group (13.8±1.0) (p-value 0.009), PCV level mean was lower in H. pylori patients (37.6±3.1) than control group (41±3.0) (p-value .036), TIBC mean was 313 in cases and 308 in control samples. All other parameters showed no significant difference between H. pylori positive patients and control subjects. Conclusion: This study concluded that H. pylori infection is lead to iron deficiency in Sudanese patients.Helicobacter pylori infectioniron deficiencySudaneseJournal ArticleIndiaDepartment of Hematology, Faculty of Medical Laboratory Science, University of Dongola, Al Dabbah, SudanDepartment of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Dongola, Al Dabbah, SudanDepartment of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Dongola, Al Dabbah, SudanDepartment of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia and Center for Artificial Intelligence in Precision Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Microbiology and Parasitology, Faculty of Medical Laboratory Science, Dongola University, SudanDepartment of Community Medicine, Faculty of Medicine, Dongola University, Sudan.