D’Souza, SharonJames, EdwinJois, RameshMahendradas, PadmamaliniKoul, AmeetaPradhan, Aditya2023-08-252023-08-252023-04D’Souza Sharon, James Edwin, Jois Ramesh, Mahendradas Padmamalini, Koul Ameeta, Pradhan Aditya. Systemic investigations in dry eye disease. Indian Journal of Ophthalmology. 2023 Apr; 71(4): 1326-13311998-36890301-4738http://imsear.searo.who.int/handle/123456789/224956The incidence of dry eye disease has increased manifold in the past few years with more patients presenting with these complaints to our clinics every day. In the more severe forms of disease, it is important to evaluate for any systemic association which could be driving the disease such as in Sjogren’s syndrome. Understanding the possible varied etiopathogenesis and knowing when to evaluate, form an important part of treating this condition effectively. In addition, it is sometimes confusing as to which investigations to order and how to prognosticate the disease in these situations. This article simplifies this into an algorithmic approach with insights from the ocular and systemic point of viewClinical relevancedry eye diseaseinvestigationssystemic DEDJournal ArticleIndiaDepartment of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, Bengaluru, Karnataka, IndiaGovernment Medical College, Paripally Kollam District, Kerala, IndiaManipal Hospital, Millers Road, Bengaluru, Karnataka, IndiaDepartment of Uveitis and Ocular Immunology, Narayana Nethralaya Eye Hospital, Bengaluru, Karnataka, IndiaCornea, External Disease and Cataract, Disha Eye Hospitals, Kolkata, West Bengal, India