Raval, P JVerma, R J2009-05-282009-05-281993-09-01Raval PJ, Verma RJ. Steroid hormones retard aflatoxin-induced cytotoxicity. Indian Journal of Experimental Biology. 1993 Sep; 31(9): 780-1http://imsear.searo.who.int/handle/123456789/59354Protective effect of sex steroid hormones on aflatoxin-induced cytotoxicity on RBC (hemolysis) was examined in vitro. Addition of aflatoxin (2 micrograms/ml) in RBC suspension caused significant increase in hemolysis. Concurrent addition of aflatoxin (2 micrograms/ml) and estradiolbenzoate (100-1200 pg/ml) in RBC suspension significantly retarded aflatoxin-induced hemolysis. Similarly, addition of aflatoxin (2 micrograms/ml) along with testosterone propionate (5-60 ng/ml) in RBC suspension retarded aflatoxin-induced hemolysis. Among the two synthetic hormones studied estradiolbenzoate was more potent than testosterone propionate.engAdultAflatoxins --antagonists & inhibitorsEstradiol --analogs & derivativesHemolysis --drug effectsHumansTestosterone --pharmacologyIn Vitro