Meliala, A.Sumiwi, Y. A. A.Narwidina, P.Rini, S. L. S.Setyaningsih, W.2020-09-242020-09-242020-08Meliala A., Sumiwi Y. A. A., Narwidina P., Rini S. L. S., Setyaningsih W.. Banana Peel Flakes Alleviate Blood Glucose And Stress In A Dose-Dependent Manner. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Aug; 12(8): 75-810975-14912656-0097http://imsear.searo.who.int/handle/123456789/206001Objective: This study aimed to evaluate the antidiabetic and antidepressant effects of banana peel flakes in streptozotocin-induced diabetic rats. Methods: Twenty-five male Wistar rats were classified into five groups with different treatments. Groups I to IV were diabetic rats model groups that consumed only standard diet, standard diet containing 5%, 10%, and 20% of banana peel flakes, respectively. While group V was a healthy control group fed a standard diet. Immunohistochemistry staining was measured to examine serotonin expression in the colon and pancreas. Results: The diabetic rats treated with 20% banana peel flakes had a lower blood glucose concentration (p<0.05) compared with diabetic control and showed a shorter duration of immobility time (p<0.05) than the healthy control. Additionally, compared with diabetic control, the diabetic rats treated with 5% banana peel flakes showed higher serotonin expression (p<0.05) in the colon. In contrast, serotonin expression in the pancreas did not show any significant difference (p>0.05). Conclusion: The present study disclosed that the banana peel flakes provided an antidepressant effect in the diabetic rats model, which might occur through the mechanism of controlling blood glucose concentration.Banana peelAntidiabeticAntidepressiveDietary fiberSerotoninJournal ArticleIndiaDepartment of Physiology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Jalan Farmako Sekip Utara, Sleman, Yogyakarta 55281, IndonesiaDepartment of Histology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Jalan Farmako Sekip Utara, Sleman, Yogyakarta 5528, IndonesiaClinical Nutrition Research Group, Yogyakarta 55133, IndonesiaDepartment of Physiology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Jalan Farmako Sekip Utara, Sleman, Yogyakarta 55281, IndonesiaDepartment of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora, Bulaksumur, Sleman, Yogyakarta 55281, Indonesia