Gopalakrishna, RNagarajan, B2015-07-182015-07-181980-12Gopalakrishna R, Nagarajan B. Arginase from rat fibrosarcoma. Its possible role in proline, glutamate and polyamine metabolism. Journal of Biosciences. 1980 Dec; 2(4): 275-282.http://imsear.searo.who.int/handle/123456789/160027The presence of arginase in rat fibrosarcoma not synthesizing urea, suggested that this enzyme may have additional functions. Ornithine carbamoyl transferase, a key enzyme of the urea cycle was absent in this tissue, when compared to normal tissues, lower amount of ornithine was found in the fibrosarcoma, but this tumour contained a higher level of proline. The radioactivity present in L-[U-14C] arginine was incorporated into putrescine, spermidine, spermine, proline glutamate and glutamine suggesting that arginine was a possible precursor and that arginase may have a role in the synthesis of these metabolites.enRat fibrosarcomaarginaseornithine carbamoyl transferasepolyaminesprolineglutamateArticle