Kalla, GGarg, AKachhawa, D2009-05-282009-05-282001-03-01Kalla G, Garg A, Kachhawa D. Chemical peeling--glycolic acid versus trichloroacetic acid in melasma. Indian Journal of Dermatology, Venereology and Leprology. 2001 Mar-Apr; 67(2): 82-4http://imsear.searo.who.int/handle/123456789/52482Melasma continues to be a therapeutic challenge. 100 patients of melasma not responding to conventional depigmenting agents were divided into 2 groups, one treated with 55-75% glycolic acid (68 patients) and the other with 10-15% trichloroacetic acid (32 patients). Applications were made after every 15 days and response assessed clinically along with relapse or hyperpigmentation after 3 month follow up period. More than 75% improvement was seen in 30%, and 50-75% improvement in 24% patients. Response with TCA was more rapid as compared to GA. Chronic pigmentation responded more favourably to TCA. Relapse and hyperpigmentation was more-25% in TCA as compared to 5.9% GA. Sun exposure was the most important precipitating factor followed by pregnancy and drugs.engJournal Article