Shankar, R PKaran, R SHandu, S SBhargava, V K2000-07-152009-06-012000-07-152009-06-012000-07-15Shankar RP, Karan RS, Handu SS, Bhargava VK. Effect of the 5-HT3 receptor antagonist ondansetron on amphetamine-induced hyperactivity and stereotypy in rats. Indian Journal of Physiology and Pharmacology. 2000 Jul; 44(3): 355-8http://imsear.searo.who.int/handle/123456789/107199The effects of different doses of ondansetron (0.1, 0.5, 1, 2 mg/kg) administered intra-peritoneally were studied on amphetamine-induced hyperactivity and stereotypy in wistar rats. Ondansetron was administered 30 minutes prior to d-amphetamine (3 mg/kg, i.p.). Ondansetron in doses of 0.5 and 1 mg/kg significantly decreased the mean number of head dippings and crossings in the hole board test and in doses of 0.1 and 0.5 mg/kg significantly decreased the average stereotypic score. Since the hyperactivity and stereotypy are dopamine mediated, the effect of ondansetron to reduce these states suggests a potential role for ondansetron in conditions with dopamine excess.engAnimalsDextroamphetamine --pharmacologyMaleMotor Activity --drug effectsOndansetron --pharmacologyRatsRats, WistarReceptors, Serotonin --physiologyReceptors, Serotonin, 5-HT3Serotonin Antagonists --pharmacologyStereotyped Behavior --drug effectsJournal Article