Demonstration Of Biofilm Formation By Gram-Negative Bacteria And Study Their AST Pattern At MGMMC, Jamshedpur, Jharkhand.

Pawar, KalyaniBaxla, VineetaBiswas, SumangalaBiswas, Binita2025-05-142025-05-142024-12Pawar Kalyani, Baxla Vineeta, Biswas Sumangala, Biswas Binita . Demonstration Of Biofilm Formation By Gram-Negative Bacteria And Study Their AST Pattern At MGMMC, Jamshedpur, Jharkhand.. Paripex - Indian Journal Of Research. 2024 Dec; 13(12): 10-122250-1991https://imsear.searo.who.int/handle/123456789/247888Introduction: Gram- negative bacteria are attributable to matrix- enclosed aggregates known as biofilms. The development of biofilms is currently recognised as one of the most relevant drivers of persistent infections and constitutes as a major challenge for clinical microbiologist and clinicians. Bacteria living in a biofilm can exhibit a 10 to 1,000-fold increase in antibiotic resistance compared to similar bacteria living in a planktonic state. Aims & Objective: The purpose of this study is to detect the biofilm formation by gram-negative bacilli and determine their antimicrobial susceptibility pattern. A cross-sectional study was conducted from January 2024 to November 2024 on 246Methods: bacterial isolates from various clinical samples to demonstrate biofilm formation by Tube Method and an antibiogram was drawn. Escherichia coli (34.15%) was the predominant gram-negative bacteria encountered, followed byResult: Pseudomonas aeruginosa (28.05%), Klebsiella pneumoniae (22.36%) and Acinetobacter baumannii (10.16%). AST revealed higher resistance to Ampicillin, Trimethoprim/ sulfamethoxazole, Amoxicillin clavulanic acid, Gentamicin and Cefepime. Biofilms are rapidly becoming a major contributor to Hospital Acquired Infections (HAI)TheConclusion: knowledge of biofilm formation and antibiogram of bacterial isolates contributing to its formation is of utmost importance for rendering reliable empirical antibiotic therapy to the patients.Biofilmgram- negative bacteriahospital acquired infections (HAI)antibiotic resistanceantibiogramDemonstration Of Biofilm Formation By Gram-Negative Bacteria And Study Their AST Pattern At MGMMC, Jamshedpur, Jharkhand.Journal ArticleIndiaSenior Resident, Mahatma Gandhi Memorial Medical College And Hospital, Jamshedpur, JharkhandSenior Resident, Sheikh Bhikhari Medical College And Hospital, Hazaribagh, JharkhandAssociate Professor, Mahatma Gandhi Memorial Medical College And Hospital, Jamshedpur, JharkhandSenior Resident, Mahatma Gandhi Memorial Medical College And Hospital, Jamshedpur, Jharkhand