Mohanty, SNongrum, DLSingh, LJDas, P2020-09-242020-09-242019-04Mohanty S, Nongrum DL, Singh LJ, Das P. Metachronous nasopharyngeal carcinoma masquerading as a base of skull metastasis in a case of primary extraskeletal vulvar Ewing’s sarcoma. International Journal of Medical Science and Public Health. 2019 Apr; 8(4): 336-3392277-338X2320-4664http://imsear.searo.who.int/handle/123456789/205436Ewing’s sarcoma (ES) and primitive neuroectodermal tumor (PNET) resemble each other and commonly affect the skeletal system. Extraskeletal ES/PNET is a rare neoplasm. Here, we report a case of primary vulvar ES in an 18-year-old adolescent girl confirmed by histopathology and immunohistochemistry, who underwent surgery followed by adjuvant chemotherapy. Following 1 year of chemotherapy, she presented with multiple cranial nerve palsies (VI, IX, X, and XII). Contrast tomography of the base of the skull and nasopharynx showed a heterogeneous mass lesion involving the base of skull, sphenoid sinus, and left nasopharynx. Biopsy from the left nasopharyngeal mass revealed it to be well-differentiated squamous cell carcinoma, which was initially thought of metastasis to the base of the skull. In spite of its aggressive nature, a patient of primary sarcoma presenting with a second lesion should be adequately investigated before considering it as a metastatic lesion.Ewing’s SarcomaExtraskeletalMetachronousNasopharyngeal CarcinomaVulvaJournal ArticleIndiaDepartment of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, Manipur, IndiaDepartment of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India