Acharya, Shrikrishna VGopal, Raju ABandgar, Tushar RJoshi, Shashank RMenon, Padma SShah, Nalini S2012-10-232012-10-232009-10Acharya Shrikrishna V, Gopal Raju A, Bandgar Tushar R, Joshi Shashank R, Menon Padma S, Shah Nalini S. Clinical profile of adrenoleukodysrophy. Indian Journal of Pediatrics. 2009 Oct; 76(10): 1045-1047.http://imsear.searo.who.int/handle/123456789/142400X-linked Adrenoleukodystrophy (ALD) is the most common of the peroxisomal disorder and is associated with functional defect of the very long chain fatty acid (VLCFA) oxidation leading to the accumulation of VLCFA in the white matter and adrenal cortex. Retrospective evaluation of medical records of ALD patients were carried out. In all the 5 patients the duration of the symptoms varied from 1-7 years. Most of them presented with Addisonian crisis (4/5) and hyperpigmentation (5/5), white half of them (3/5) had neurological symptoms. All patients had biochemical evidence of the adrenal insufficiency. All siblings of patients should be screened for the possibility of ALD with VLCFA.enAdrenoleukodystrophyVLCFA (very long chain fatty acids)Hyperkinetic behaviour: BMT (bone marrowAddison Disease --etiologyAddison Disease --physiopathologyAdrenal Cortex Hormones --therapeutic useAdrenocorticotropic Hormone --bloodAdrenoleukodystrophy --complicationsAdrenoleukodystrophy --diagnosisAdrenoleukodystrophy --drug therapyAdrenoleukodystrophy --geneticsBlood Chemical AnalysisChildChild, PreschoolFatty Acids, Nonesterified --metabolismFollow-Up StudiesHumansMaleRetrospective StudiesRisk AssessmentSampling StudiesSeverity of Illness IndexTreatment OutcomeArticle