Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India

Habbu, Prasanna V.Miskin, NarayanVenkatrao, H. KulkarniBhat, PradeepJoshi, ArunBhandarkar, AnantKulkarni, SatishDixit, Sheshagiri R.Vaijanathappa, Jaishree2020-10-162020-10-162020-03Habbu Prasanna V., Miskin Narayan, Venkatrao H. Kulkarni, Bhat Pradeep, Joshi Arun, Bhandarkar Anant, Kulkarni Satish, Dixit Sheshagiri R., Vaijanathappa Jaishree. Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India. Journal of Applied Pharmaceutical Science. 2020 Mar; 2020 Mar: 135-1482231-3354http://imsear.searo.who.int/handle/123456789/210718Bauhinia foveolata Dalzell is an endemic tree, native to Southwest India (the Western Ghats). 13-Docosenamide wasisolated from ethyl acetate fraction, and quercetin (1), isorhamnetin (2), and odoratin-7-glucoside (3) were isolatedfrom butanol fraction of leaves. A spectroscopic analysis, including mass spectra and Nuclear Magnetic Resonance(NMR), and also comparison with reported data were used to elucidate the chemical structures of isolated compounds.Furthermore, all the isolated compounds were analyzed for 3-(4, 5-dimethylthiazol-2-yl)-5-diphenyltetrazoliumbromide -based cytotoxicity studies on human colon cancer cell lines, HT-29 and HCT-15; among all the testedcompounds, quercetin and odoratin-7-glucoside have shown a good cytotoxicity toward the selected cell lines.Bauhinia foveolata13-DocosenamideflavonoidscytotoxicityIsolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, IndiaJournal ArticleIndiaPostgraduate Department of Pharmacognosy and Phytochemistry, SET’s College of Pharmacy, Dharwad 580 002, India.Postgraduate Department of Pharmacognosy and Phytochemistry, SET’s College of Pharmacy, Dharwad 580 002, India.Postgraduate Department of Pharmacology, SET’s College of Pharmacy, Dharwad 580 002, India.Indian Council of Medical Research, National Institute of Traditional Medicine, Belagavi 590 010, India.Department of Pharmacognosy, Goa College of Pharmacy, Panaji, IndiaDepartment of Pharmacognosy, Goa College of Pharmacy, Panaji, IndiaB N Degree College, Dandeli 581 325, India.Department of Pharmaceutical Chemistry, JSS College of Pharmacy, S S Nagar, Mysuru 570015, IndiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, S S Nagar, Mysuru 570015, India