Kumar, VSingh, P NMuruganandam, A VBhattacharya, S K2009-05-282009-05-282000-11-09Kumar V, Singh PN, Muruganandam AV, Bhattacharya SK. Hypericum perforatum: nature's mood stabilizer. Indian Journal of Experimental Biology. 2000 Nov; 38(11): 1077-85http://imsear.searo.who.int/handle/123456789/55731113 references.Hypericum perforatum (HP), better known as St. John's Wort, has been used clinically for centuries. Modern usage is still quite diverse and includes kidney and lung ailments, insomnia and depression. Standardised extracts of HP are widely used in the treatment of psychovegetative disorders and especially for mild forms of depression. Several bioactive constituents of this plant may play important role in its well-known antidepressant activity, which are discussed in the present article. Furthermore, emphasis is also given on its botany, chemistry, pharmacology and clinical efficacy.engAntidepressive Agents --therapeutic useAntiviral Agents --pharmacologyDepression --drug therapyHumansHypericum --chemistryPhytotherapyPlant Extracts --pharmacologyPlants, MedicinalProtein Kinase C --antagonists & inhibitorsWound Healing --drug effectsJournal Article