Mostafa, Hasan RajibFariduddin, Md.Selim, ShahjadaHasanat, M AIslam, MoinulHoque, FazlulMustari, MarufaMahjabeen, Samira2020-09-242020-09-242020-03Mostafa Hasan Rajib, Fariduddin Md., Selim Shahjada, Hasanat M A, Islam Moinul, Hoque Fazlul, Mustari Marufa, Mahjabeen Samira. Serum Zinc Level in Persons with Prediabetes and it’s Relation with Glycemic Status Attending Tertiary Care Hospital in Bangladesh. International Journal of Medical Research Professionals. 2020 Mar; 6(2): 63-682454-63642454-6356http://imsear.searo.who.int/handle/123456789/203581Background: Type 2 diabetes mellitus is becoming one of themajor health problems worldwide. Especially in South EastAsia, type 2 diabetes has gained critical significance. Asprediabetes prevalence is increasing worldwide, it has becomean important concern to prevent diabetes at an early stage inBangladesh.Objectives: Estimation of serum zinc level and establishmentof its relation with glycemic status in individuals with prediabetes.Materials and Methods: This cross-sectional studyencompassed 126 (age: 35.09±9.96 years, mean ± SD; Sex:16/110, M/F) subjects with prediabetes and 126(age:29.08±9.28 years, mean ± SD; Sex: 22/104, M/F) healthynondiabetic controls from the out-patient department ofEndocrinology, BSMMU consecutively. Serum zinc wasmeasured by using Atomic Absorption Spectrophotometry.Height, weight, waist circumference, acanthosis nigricans,hypertension, SGPT& serum creatinine were recorded asconfounding variables.Results: Serum zinc level in persons with prediabetes waslower than that in control (0.76±0.01 vs. 0.78±0.01mg/L,M±SEM, p=0.28). There was statistically significant differencefor zinc level in gender groups (M vs. F: 0.84±0.02 vs.0.75±0.01 mg/L, M±SEM, p<0.001) and monthly family incomegroups (p=0.02). Also zinc level was statistically similar amongglycemic status groups apart from zinc level in between controland combined glucose intolerance (CGI) groups (control vs.CGT: 0.78±0.01 vs. 0.72±0.02mg/L, M±SEM, p=0.03). Amongcases comparisons between groups with or without risk factorslike: smoking (0.72±0.03 vs. 0.76±0.10 mg/L, p=0.42),smokeless tobacco (0.73±0.03 vs. 0.76±0.01mg/L, p=0.46),hypertension (0.80±0.03 vs. 0.75±0.01 mg/L, p= 0.14), familyhistory of DM (0.75±0.02 vs. 0.77±0.02mg/L, p=0.52), familyhistory of CVD (0.74±0.02vs.0.77±0.01mg/L,p=0.28), overweight (0.76±0.01 vs.0.74±0.05mg/L, P=0.59), waistcircumference (0.75±0.01 vs. 0.79±0.04mg/L, p=0.40) andacanthosis nigricans (0.75±0.02 vs. 0.76±0.02mg/L, p=0.70),showed no statistically significant difference. None of thevariables like age (r= -0.02, p=0.19), BMI (r= 0.14, p=0.12),FPG (r= -0.05, p=0.60) and PG 2h after 75g glucose (r=0.10,p=0.28), HbA1c (r=0.04, p=0.64), serum creatinine (r=0.01,p=0.87) showed significant relationship with the level of zincexcept SGPT which showed significant relation with zincamong cases (r= 0.28, p=0.002) and among all participants(r=0.17, p=0.008) but not in control group (r=0.07, p=0.43).Conclusion: It is concluded that persons with prediabetes hadserum zinc level within normal limit and there was found nostatistically significant relationship between HbA1c and zincDiabetes MellitusSerum Zinc LevelPrediabetesGlycemic StatusJournal ArticleIndiaMedical Officer, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, BangladeshChairman &Professor, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, Bangladesh.Associate Professor, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, BangladeshProfessor, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, BangladeshAssistant Professor, Dept. of Endocrinology, Dhaka Medical College Hospital (DMCH), Dhaka, BangladeshLecturer, Dept. of Community Medicine, Shahid Sayed Nazrul Islam Medical College, Kishoregonj, Banglades