Waghmare, MandaviPagare, SandeepBhor, KetakiSrivastava, RichaManoj, ReemaGavand, Kapil2024-11-302024-11-302024-07Waghmare Mandavi, Pagare Sandeep, Bhor Ketaki, Srivastava Richa, Manoj Reema, Gavand Kapil . Comparing efficacy of curcumin with other treatment modalities in oral submucous fibrosis management - A systematic review and meta-analysis. Journal of Ayurveda and Integrative Medicine. 2024 Jul; 15(4): 1-100975-9476https://imsear.searo.who.int/handle/123456789/236974Background: Oral Submucous Fibrosis, OSF is an inflammatory mucosal disorder prevalent in areca nut chewing belts of the world. Although various treatments are available for its management, none provide complete res- olution.Curcumin, an indigenous product, improves burning sensation, mouth opening along with other clinical signs of OSF and is potentially viable therapeutic option for its management. Objectives: To assess the available evidence for employing curcumin in improving symptoms in patients with OSF. Methods: Systematic search was carried out in e-databases from January 2010 until July 2023 to identify relevant clinical trials comparing curcumin to active and/or nonactive controls (placebo) for the management of OSF. Results: A total of 20 studies were used for qualitative analysis out of which 11 studies were considered for quantitative synthesis.Curcumin was found to be highly effective in alleviating pain/burning sensation, improving mouth opening (MO), cheek flexibility, tongue protrusion and induces positive histological changes in patients with OSF.The standardized mean difference in mouth opening between both the Curcumin and Multi- vitamin group showed a statistically significant difference favouring the Curcumin group (SMD, 0.37, 95% CI = 0.18–0.56, p - 0.0001, I2- 0%). Conclusion: Statistically curcumin was noted to be as effective as Aloe vera, lycopene and steroids in relieving symptoms of OSF in stages 1 and 2 and improving MO. It is seen to improve histopathological picture of lesions thereby suggesting its active role in preventing malignant transformation. Its found to be more effective than multivitamins in improving mouth opening of patients in OSF.CurcuminTrismusFibrosesOral submucousJournal ArticleIndiaDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Sector 7, Nerul, Navi, Mumbai, 400706, IndiaDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, IndiaQuality, compliance and marketing, Masina Hospital, Byculla, Mumbai, IndiaDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, IndiaDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, IndiaDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, India