Kathuria, SushrutaGautam, YuganshKhunger, NitiSharma, ShrutiSingh, Ruchi2025-08-132025-08-132025-06Kathuria Sushruta, Gautam Yugansh, Khunger Niti, Sharma Shruti, Singh Ruchi. Reworking the treatment of Indian Post kala-azar dermal leishmaniasis: A two-step therapy. Journal of Vector Borne Diseases . 2025 Jun; 62(2): 248-2510972-9062https://imsear.searo.who.int/handle/123456789/252562In the current scenario, treatment of Post kala-azar dermal leishmaniasis (PKDL) is intravenous liposomal amphotericin B or oral miltefosine. Over the years, there has been a gradual decline in the efficacy of miltefosine and a rise in permanent loss of vision. Moreover, in non-endemic states of India, miltefosine is not freely available. In view of this, we attempted a two-step regimen of liposomal amphotericin B and itraconazole to treat two patients of PKDL diagnosed on histopathology as well as PCR. We found this treatment to be highly effective with complete recovery.post kala azar dermal leishmaniasisitraconazoleamphotericin BJournal ArticleIndiaDepartment of Dermatology and Venerology, Safdarjung Hospital and V Vardhaman Mahavir Medical College, New Delhi, IndiaDepartment of Dermatology and Venerology, Safdarjung Hospital and V Vardhaman Mahavir Medical College, New Delhi, IndiaDepartment of Dermatology and Venerology, Safdarjung Hospital and V Vardhaman Mahavir Medical College, New Delhi, IndiaICMR- National Institute of Pathology, New Delhi, IndiaICMR- National Institute of Pathology, New Delhi, India