Nallamothu, Murali KrishnaC., Mandava Radha ManiVeera, Abhinav ChintaT., Jaya Chandra2020-05-062020-05-062020-01Nallamothu Murali Krishna, C. Mandava Radha Mani, Veera Abhinav Chinta, T. Jaya Chandra . Evaluation of neo adjuvant chemotherapy response in patients with locally advanced breast cancer. International Journal of Clinical Trials. 2020 Jan; 7(1): 32-342349-32402349-3259http://imsear.searo.who.int/handle/123456789/200962Background:Carcinoma of the breast from the very beginning has been a feared disease. Advanced disease is treated by neoadjuvant chemotherapy (NACT). With this, a study was conducted to evaluate the pathologic response to NACT in locally advanced breast cancer.Methods:Study was conducted in GSL Medical College, approved by institutional ethics committee, females aged >18 years with locally advanced breast cancer were included in the study. Female <18 years and breast cancer male were not considered. The dimensions are marked and size of the lump compared before and after NACT. Chi-square test was used to find out the significance of study parameters; p<0.05 was considered statistically significant.Results:Total 110 patients were included in the study, mean age was50.63±10.76 years and 53% were in pre menopausal women. When pathological response was considered, 12.7% had complete response, 66.4% had partial response and 20.9% had no response to NACT; statistically there was significant difference between pre and post treatment tumor sizes (p<0.05).Conclusions: Most of the individuals belonged to premenopausal group. Tumour size showed significant decrease after NACT. The overall response rate (completeand partial) after NACTwas significant in our study groupBreastCancerChemotherapyJournal ArticleIndiaDepartment of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh , IndiaCentral Research Laboratory, GSL Medical College, Rajahmundry, Andhra Pradesh India