Khanna, VikrantAlam, SeemaMalik, AshrafMalik, Abida2005-11-052009-05-302005-11-052009-05-302005-11-05Khanna V, Alam S, Malik A, Malik A. Efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea. Indian Journal of Pediatrics. 2005 Nov; 72(11): 935-8http://imsear.searo.who.int/handle/123456789/78313OBJECTIVE: A double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea. METHODS: All children from 6 months to 12 years with acute diarrhea were included. Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 received lactobacillus and 50 the placebo. RESULTS: ORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in the lactobacillus group and none in the placebo group (OR 0.92, 95%CI 0.84-0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance. CONCLUSION: There is no significant benefit of tyndalized Lactobacillus acidophilus in acute diarrhea.engAcute DiseaseChildChild, PreschoolCombined Modality TherapyDiarrhea --therapyDouble-Blind MethodFluid TherapyHumansInfantLactobacillus acidophilusProbiotics --therapeutic useJournal Article