Bhandare, P NRataboli, P VDiniz D'Souza, R SDhume, V G1992-04-012009-06-011992-04-012009-06-011992-04-01Bhandare PN, Rataboli PV, Diniz D'Souza RS, Dhume VG. Aggravating action of hydralazine on ethanol-induced gastric lesions. Indian Journal of Physiology and Pharmacology. 1992 Apr; 36(2): 130-2http://imsear.searo.who.int/handle/123456789/108449Endogenous nitric oxide has been proposed as one of the mediators of gastric cytoprotection. We studied the effect of the vasodilator hydralazine which acts via nitric oxide and thus is expected to have a gastroprotective action. However, hydralazine aggravates ethanol-induced gastric lesions. This effect is not influenced by pretreatment with the selective alpha 1 adrenergic antagonist prazosin but is abolished by the angiotensin converting enzyme inhibitor, captopril suggesting the involvement of the renin-angiotensin system.engAnimalsCaptopril --pharmacologyDrug InteractionsEthanol --toxicityGastrointestinal Hemorrhage --chemically inducedHydralazine --administration & dosageMalePrazosin --pharmacologyRatsRats, Inbred StrainsStomach --drug effectsStomach Diseases --chemically inducedJournal Article