Fajar, Jonny KaruniaPikir, Budi SusetioSidarta, Erdo PuncakSaka, Putu Nina BerlindaAkbar, Rizal RahmandaHeriansyah, Teuku2020-01-022020-01-022019-05Fajar Jonny Karunia, Pikir Budi Susetio, Sidarta Erdo Puncak, Saka Putu Nina Berlinda, Akbar Rizal Rahmanda, Heriansyah Teuku. The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis. Indian Heart Journal. 2019 May; 71(3): 199-2060019-4832http://imsear.searo.who.int/handle/123456789/191690Objectives The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. Methods Information related to the sample size and genotype frequencies was extracted from each study. Results Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. Conclusions Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy.Left ventricular hypertrophyAngiotensin-converting enzymeACE I/DACE G2350AJournal ArticleIndiaMedical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60115, IndonesiaBrawijaya Cardiovascular Research Center, Universitas Brawijaya, Malang, 65145, IndonesiaDepartment of Emergency, Wava Husada Hospital, Malang, 65163, IndonesiaDepartment of Cardiology and Vascular Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia