Bhargava Periwal, SFarooq, ABhargava, V LBhatla, NVij, UMurugesan, K2009-05-282009-05-281995-12-01Bhargava Periwal S, Farooq A, Bhargava VL, Bhatla N, Vij U, Murugesan K. Tamoxifen increases the proliferation of human endometrial stromal cells in in vitro. A model for evaluation of endometrial hyperplasia. Indian Journal of Experimental Biology. 1995 Dec; 33(12): 977-9http://imsear.searo.who.int/handle/123456789/61182Tamoxifen given for breast cancer therapy, has a complex and an unclear action on the endometrium. A large number of literatures has attributed the proliferous changes in the endometrium caused by tamoxifen (Tam). No report has appeared on the endometrial cellular changes induced by Tam. The present study shows a significant (P < 0.001) increase in the proliferative activity due to Tam in endometrial stromal cells over control and estradiol (E2). This in vitro model is useful for the study of the hyperplasic effect of Tam at the cellular level.engCell Division --drug effectsEndometrial Hyperplasia --chemically inducedEndometrium --drug effectsEvaluation Studies as TopicFemaleHumansModels, BiologicalStromal Cells --drug effectsTamoxifen --pharmacologyJournal Article