Ismail, Nagwa AbdallahMetwaly, Nermeen Salah EldinEl-Moguy, Fatma AhmedHafez, Mona HassanDayem, Soha M Abd ElFarid, Tarek Mohamed2012-06-082012-06-082010-09Ismail Nagwa Abdallah, Metwaly Nermeen Salah Eldin, El-Moguy Fatma Ahmed, Hafez Mona Hassan, Dayem Soha M Abd El, Farid Tarek Mohamed. Bone age is the best predictor of growth response to recombinant human growth hormone in Turner’s syndrome. Indian Journal of Human Genetics. 2010 Sept; 16(3): 119-126.http://imsear.searo.who.int/handle/123456789/138910BACKGROUND AND OBJECTIVES: Recombinant human growth hormone (rhGH) is approved for use in children with Turner’s syndrome (TS) in most industrialized countries and is recommended in the recently issued guidelines. We determined the growth responses of girls who are treated with rhGH for TS, with an aim to identify the predictors of growth response. MATERIALS AND METHODS: Fifty-six prepubertal girls with TS, documented by peripheral blood karyotype, were enrolled. All the patients received biosynthetic growth hormone therapy with a standard dose of 30 IU/m2/week. The calculated dose per week was divided for 6 days and given subcutaneously at night. RESULTS: This study showed that rhGH therapy provides satisfactory auxological results. Bone age delay is to be considered as a predictive factor which may negatively influence the effect of rhGH therapy on final height. The growth velocity in the preceding year is the most important predictor of rhGH therapy response. CONCLUSION: These observations help us to guide rhGH prescription, to reduce the risks and costs.enBone agegrowth hormone therapyTurner’s syndromeAge Determination by Skeleton --methodsChildEgypt --epidemiologyFemaleHuman Growth Hormone --administration & dosageHuman Growth Hormone --geneticsHuman Growth Hormone --therapeutic useHumansPubertyTurner Syndrome --epidemiologyTurner Syndrome --drug therapyTurner Syndrome --geneticsArticle