Chugh, YSankaranarayanan, ASharma, P L1994-04-012009-06-011994-04-012009-06-011994-04-01Chugh Y, Sankaranarayanan A, Sharma PL. Possible mechanism of endosulfan-induced enhancement of memory acquisition and retention in mice. Indian Journal of Physiology and Pharmacology. 1994 Apr; 38(2): 138-40http://imsear.searo.who.int/handle/123456789/108577The effects of pre-training and post-training administration of endosulfan on retention of a step-down passive avoidance task was studied in mice. Endosulfan at doses of 1.0 mg/kg(ip) and 2.0 mg/kg(ip) enhanced memory acquisition and retention. This effect of endosulfan was possibly mediated by interaction with cholinergic neurotransmission, as scopolamine (0.5 mg/kg, ip) significantly antagonized the memory enhancing effects of endosulfan. Clonidine (0.05 mg/kg, ip) did not have any effect on enhancement of memory produced by endosulfan, thus indicating possibly no role of noradrenergic system.engAnimalsAvoidance Learning --drug effectsClonidine --pharmacologyDose-Response Relationship, DrugDrug InteractionsEndosulfan --administration & dosageInjections, IntraperitonealMaleMemory --drug effectsMiceScopolamine --pharmacologySynaptic Transmission --drug effectsComparative Study