Lumbiganon, PPanamonta, O2009-05-272009-05-272000-03-07Lumbiganon P, Panamonta O. Imipenem therapy for septicemic melioidosis in a child with penicillin and cephalosporin adverse reaction. The Southeast Asian Journal of Tropical Medicine and Public Health. 2000 Mar; 31(1): 89-90http://imsear.searo.who.int/handle/123456789/33424The Southeast Asian Journal of Tropical Medicine and Public Health.The recommended treatment for severe melioidosis is ceftazidime or a combination of ceftazidime and trimethoprim-sulfamethoxazole (TMP/SMX). Amoxicillin-clavulanate has been shown to be an effective alternative therapy. In patient who is allergic to penicillin and cephalosporin, imipenem an alternative drug may be used. We described a 10 year-old boy who was diagnosed as septicemic melioidosis and type 1 diabetes mellitus. He developed fever and rash while being given ceftazidime and TMP/SMX. The fever recurred when amoxicillin-clavulanate was administered orally. He was successfully treated with imipenem.engAmoxicillin-Potassium Clavulanate Combination --adverse effectsAnti-Bacterial Agents --adverse effectsBacteremia --complicationsCeftazidime --adverse effectsCephalosporins --adverse effectsChildDiabetes ComplicationsDrug Therapy, Combination --adverse effectsHumansImipenem --therapeutic useMaleMelioidosis --complicationsThienamycins --therapeutic useCase Reports