Basu, AnalabhaMajumder, Partha P2003-04-252009-06-022003-04-252009-06-022003-04-25Basu A, Majumder PP. A comparison of two popular statistical methods for estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences. Journal of Genetics. 2003 Apr-Aug; 82(1-2): 7-12http://imsear.searo.who.int/handle/123456789/114344We have compared two statistical methods of estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences, which have been proposed by Templeton (1993) and Bandelt et al. (1995). Monte-Carlo simulations were used for generating DNA sequence data. Different evolutionary scenarios were simulated and the estimation procedures were evaluated. We have found that for both methods (i) the estimates are insensitive to demographic parameters and (ii) the standard deviations of the estimates are too high for these methods to be reliably used in practice.engAlgorithmsAnimalsComputer SimulationDNA --geneticsDemographyEvolution, MolecularHumansModels, GeneticMonte Carlo MethodStatistics as TopicTime FactorsComparative Study