Ripa, Rokhsana AlamIslam, Shafiqul2024-09-242024-09-242024-06Ripa Rokhsana Alam, Islam Shafiqul . Cardiometabolic Risk Factors in Relation to Serum NT-Pro-BNP level: A Cross-Sectional Study Among CKD Patients. International Journal of Medical Research Professionals. 2024 May; 10(3): 1-62454-63562454-6364https://imsear.searo.who.int/handle/123456789/231027Introduction: CKD patients suffer from increased rate of mortality and morbidity due to cardiovascular diseases, compared to general population. Cardiometabolic biomarker N- Terminal Pro-BNP has become a useful tool for quick screening and assessment for cardiovascular diseases. The aim of the present study is to find out the relationship between serum NT-Pro-BNP level and cardiometabolic risk factors among CKD patients without symptoms or history of cardiac diseases. Materials & Methods: This cross-sectional study among 149 CKD patients was conducted from January to December 2020 at National Institute of Kidney Diseases and Urology (NIKDU), Dhaka. Anticoagulant free venous blood samples were assayed for serum NT-Pro-BNP by electrochemiluminescence immunoassay. Serum creatinine, total cholesterol, triglyceride, high-density lipoprotein, calcium, phosphate, uric acid, eGFR, albumin and total protein of the study population were assessed and recorded during data collection. Results: Mean age of study population was 50.0 ± 12.4 years, male predominant (53%). Mean serum NT-Pro-BNP level was lowest (335.7 ± 213.3 pg/ml) for patients with CKD stage 1 and highest (15644.6 ± 2197.5 pg/ml) for patients with CKD stage 5. Mean serum creatinine was lowest (1.55 ± 1.54 mg/dl) for CKD stage 1 patients and highest (5.71 ± 2.75 mg/dl) for CKD stage 5 patients and this was statistically significant (p < 0.05). Mean serum total cholesterol, triglyceride, phosphate and uric acid were increased with disease severity and this increase was statistically significant (p < 0.05). Mean eGFR, serum albumin and total protein were decreasing with disease severity, and this decrease was also statistically significant (p < 0.05). Serum NT-Pro-BNP had significant positive correlation (r = 0.61, p < 0.05) with serum creatinine and significant negative correlation with total cholesterol, triglycerides, serum phosphorus, serum uric acid, eGFR and serum albumin. Conclusion: Serum NT-Pro-BNP could be the potential screening tool for CKD with cardiovascular diseases and can provide prognostic information of major cardiovascular events.NT-Pro-BNPCardiometabolic Risk FactorsCKDJournal ArticleIndiaJunior Consultant of Nephrology, Sheikh Russel National Gastroliver Institute & Hospital, Dhaka, BangladeshAssistant Professor, Department of Haematology, Bangabandhu Sheikh Mujib MedicalUniversity, Dhaka, Bangladesh