Jain, G LPasricha, J SGuha, S K1986-04-012009-05-281986-04-012009-05-281986-04-01Jain GL, Pasricha JS, Guha SK. An attempt to reduce the loss of pain and touch sensations in leprosy patients. Indian Journal of Leprosy. 1986 Apr-Jun; 58(2): 225-32http://imsear.searo.who.int/handle/123456789/55472An attempt was made to improve the perception of pain and touch sensations at the leprosy lesions. The loss of pain and touch sensations in a lesion was graded using Pain/Touch-Sensation-Testing-and-Grading devices. Application of a solution containing 1 mg of histamine per ml of DMSO, at the affected area decreased the grades of the loss of pain sensation in 11 (31.4%) patients and of touch sensation in 8 (22.8%) patients, out of the 35 patients tested, indicating an improvement in the perception at the lesion. This effect, however, did not persist even for 5 minutes. A higher concentration (2 mg/ml) of histamine produced reduction in the sensory loss in a larger percentage (47% for pain and 35.3% for touch) of patients, though the duration of this effect was still not prolonged.engAdolescentAdultAgedAged, 80 and overChildDimethyl Sulfoxide --pharmacologyDrug CombinationsFemaleHistamine --analogs & derivativesHumansLeprosy --physiopathologyMaleMiddle AgedNervous System Diseases --physiopathologyPain --physiopathologyPain MeasurementSensory Thresholds --drug effectsTemperature Sense --drug effectsTouchJournal Article