Bhattacharyya, PalasDas, RamaLath, AbhisekGuha, Debasish2024-09-242024-09-242024-02Bhattacharyya Palas, Das Rama, Lath Abhisek, Guha Debasish . Expression of Her2/Neu, VEGF, and Ki-67 in Epithelial Ovarian Carcinomas: An Experience from a Tertiary Care Center, West Bengal, India. International Journal of Contemporary Medical Research. 2024 Feb; 11(2): 1-62393-915X2454-7379https://imsear.searo.who.int/handle/123456789/228179Introduction: Ovarian carcinomas is still maintaining pivotal role among gynecological malignancy regarding cancer death in women. This study aims to observe expression pattern of VEGF, Her2/Neu and Ki-67 in lieu of targeted therapy for ovarian carcinoma. Materials and Methods: It was retrospective observational study carried out for last 3 years (2020-2022). A total of 160 cases of Ovarian tumors were received from different departments. The specimens were processed, histopathological sections were examined under Hematoxylin and Eosin stain, Immunohistochemical stains like VEGF, Her2/Neu and Ki-67. Evaluation was done by trained and independent pathologists. Correlation of Histological type, grade, age group. FIGO stage with expression of VEGF, Her2/Neu, and Ki-67 done. Results: Out of 160 specimens of histological examination proved 143 EOC- serous type constituted maximum (53.1 %) number. Among them (63.7%) were high grade and most of the cases belonged to 41.3% (59/143) in FIGO stage I in our study. Grade 3+ HER2/neu immunostaining was identified in 22.37% cases and had significantly correlated with tumor grade (?2 = 19.7981 with Yates correction; P <0.00001) and FIGO Staging (p=0.00024). Among High grade EOC, High proliferation index (HPI) was 19.5% for Ki-67. we could observe significant statistical association of Ki-67 HPI and tumor differentiation. Moreover, significant correlations was found between the high-grade EOC and HPI of Ki-67/Her2- neu co-expression (p<0.05). Though significant association was found between tumor grade and VEGF expression (?2 = 11.1041; P = .000861) but no correlation were in VEGF/Her-2/neu HPI and the degree of tumor differentiation (chi-square, p>0.05). Conclusion: Role of Her2/Neu and Ki-67 expression and their association should be considered in the progression and tumor grade and stage of EOC.Epithelial Ovarian CarcinomaHER2/NEUKI-67 Co-expressionJournal ArticleIndiaAssociate Professor, Department of PathologyAssociate Professor, Department of Pathology, 3 Demonstrator, Department of PathologyProfessor, Department of Pathology, NRS Medical College and Hospital, West Bengal, India