Bhatnagar, SNigam, VGuru, P YKatiyar, J CMukherjee, AGupta, R CBatra, SSeth, MBhaduri, A P2009-05-282009-05-281992-07-01Bhatnagar S, Nigam V, Guru PY, Katiyar JC, Mukherjee A, Gupta RC, Batra S, Seth M, Bhaduri AP. Effect of five-membered heterocycles against Leishmania donovani infection. Indian Journal of Experimental Biology. 1992 Jul; 30(7): 619-23http://imsear.searo.who.int/handle/123456789/62962Impact of change of heteroatom in pentavalent heterocycles, viz., pyrroles, isoxazoles, imidazoles and crotonates on the profile of antileishmanial activity against amastigotes of L. donovani using in vivo test system and macrophage-amastigote culture system has been studied. Sixty-three compounds were tested. Nine imidazoles showed marginal activity in vivo, whereas 3 out of 10 compounds of isoxazolone series and 2 out of 4 substituted aminocrotonates exhibited antileishmanial activity. Of the 30 substituted pyrroles, except 8 all showed antileishmanial activity in vivo on day 7 post treatment.engAnimalsCricetinaeHeterocyclic Compounds --therapeutic useLeishmaniasis, Visceral --drug therapyMaleJournal Article