Paliwal, PalakHuda, TanweerulAnand, KrishnanandShivani, ManishMishra, Navneet2020-11-182020-11-182020-10Paliwal Palak, Huda Tanweerul, Anand Krishnanand, Shivani Manish, Mishra Navneet. A prospective observational study: combined irrigation of bupivacaine at the gallbladder fossa with infiltration at port site for postoperative pain relief after laparoscopic cholecystectomy. International Surgery Journal. 2020 Oct; 7(10): 3340-33432349-33052349-2902http://imsear.searo.who.int/handle/123456789/213245Background: Laparoscopic cholecystectomy is a well-established procedure for gallbladder disease. Pain in laparoscopic cholecystectomy is associated with multiple factors: somatic, visceral, and phrenic nerve irritation. Effective analgesic support should, therefore, be a multimodal approach following laparoscopic surgery for better patient compliance.Methods: A prospective, randomized observational study was undertaken at a tertiary research center for a period of two years (2018-2020). 160 patients undergoing laparoscopic cholecystectomy were chosen and randomized using a computer program into 2 groups. No infiltration was given in the control population. The study group was irrigated with a 0.5% bupivacaine solution (20cc in 30 ml normal saline).Results: The bupivacaine group required fewer analgesics in comparison to the control faction, with less pain at 6 hrs. The timing of oral intake and ambulation were comparable in both factions.Conclusions: Combined bupivacaine use led to a considerable decrease in postoperative pain thereby leading to decreased analgesic use.Laparoscopic cholecystectomyBupivacaineAnalgesiaPort site infiltrationGall bladderfossa infiltrationJournal ArticleIndiaDepartment of General Surgery, Lakshmi Narain Medical College, Bhopal, IndiaDepartment of Anaesthesia, Lakshmi Narain Medical College, Bhopal, India