Hiwale, A RDhuley, J NNaik, S R2009-05-282009-05-282002-03-15Hiwale AR, Dhuley JN, Naik SR. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian Journal of Experimental Biology. 2002 Mar; 40(3): 277-81http://imsear.searo.who.int/handle/123456789/59955Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of piperine on microsomal metabolising enzymes or enzymes system.engAlkaloidsAmoxicillin --administration & dosageAnimalsAnti-Bacterial Agents --administration & dosageBenzodioxolesBiological AvailabilityCefadroxil --administration & dosageCefotaxime --administration & dosageDrug InteractionsFemaleMaleMicePiperidines --administration & dosagePolyunsaturated AlkamidesRatsJournal Article