Kaushik, GGSoni, Reena2020-05-052020-05-052018-07Kaushik GG, Soni Reena . Pseudocholinesterase As A Predictor Marker In Hypothyroid Patients . International Journal of Clinical and Biomedical Research. 2018 Jul; 4(3): 27-292395-04712521-0394http://imsear.searo.who.int/handle/123456789/200816Introduction: Hypothyroidism is due to decreased circulating levels of Thyroid hormones and is caused by inade-quate functioning of thyroid gland. Pseudocholinesterase (PCHE) is a nonspecific cholinesterase enzyme that hydro-lyses choline based esters in plasma. The purpose of this study was to evaluate the serum level of PCHE in hypothy-roid patients. Methodology:The present study was conducted on 100 newly diagnosed hypothyroid patients attend-ing the Medical OPD. The results of patients were compared with 100 healthy controls of either sex of similar age group. Anthropometric measurements, T3, T4, TSH, PCHE & Cholesterol estimations were performed. Results:The mean serum PCHE (decrease) level was observed statistically highly significant (p<0.001) in hypothyroid patients as compared with healthy control subjects. A highly significant positive correlation between PCHE with T3 & T4 (p< 0.001) in hypothyroid cases. Conclusion:Serum Pseudocholinesterase may be helpful as biomarker in screening test for hypothyroidism along with thyroid stimulating hormone.HypothyroidismThyroid ProfilePseudocholinesteraseJournal ArticleIndiaSr.Professor & HOD, J.L.N. Medical College, Ajmer, Rajasthan, India.Resident, Department of Biochemistry, J.L.N. Medical College, Ajmer, Rajasthan, India.