Saran, ABGada, MB.2025-06-182025-06-182025-04Saran AB, Gada MB.. Barriers and facilitators of human papillomavirus vaccination uptake in India: A systematic review. Indian Journal of Medical Sciences. 2025 Apr; 77(1): 34-391998-36540019-5359https://imsear.searo.who.int/handle/123456789/249721Objectives Human papillomavirus (HPV) is a primary cause of cervical cancer, a major public health concern in India. Despite the availability of HPV vaccines, uptake remains suboptimal due to various barriers. This systematic review aims to explore the barriers and facilitators influencing HPV vaccination in India. Materials and Methods A systematic search of PubMed, Google Scholar, ScienceDirect, and Livivo databases was conducted following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Inclusion criteria included studies from 2014 to 2024 that focused on HPV vaccination awareness, barriers, and facilitators in India. Data were synthesized narratively due to heterogeneity among studies. Results Thirteen studies were included. Key barriers identified were cost, lack of awareness, misinformation, and sociocultural factors. Facilitators included educational interventions, physician recommendations, and subsidized vaccination programs. School-based campaigns and community engagement were effective in improving vaccine acceptance. However, marginalized populations and out-of-school girls remain underserved. Conclusion Addressing economic and sociocultural barriers, enhancing awareness, and expanding targeted vaccination programs are essential to improve HPV vaccination rates in India. Aligning these efforts with the World Health Organization’s 90/70/90 strategy can significantly reduce the cervical cancer burdenHealth educationHuman papillomavirus vaccineHuman papillomavirusVaccination coveragesJournal ArticleIndiaHinduhridaysamrat Balasaheb Thackeray Medical College and Dr. R. N. Cooper Municipal General Hospital, Mumbai, Maharashtra, IndiaSmt Mathurabai Bhausaheb Thorat Sevabhavi Trust Institute of Medical Sciences and Research Centre, Nashik, Maharashtra, India.