Gadage, Vijaya SSubramanian, P GGalani, Komal SSehgal, Kunal KJohari, Sachin PGhogale, Vijay SBadrinath, YAshok, KGujral, Sumeet2012-10-112012-10-112011-07Gadage Vijaya S, Subramanian P G, Galani Komal S, Sehgal Kunal K, Johari Sachin P, Ghogale Vijay S, Badrinath Y, Ashok K, Gujral Sumeet. Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 599-602.http://imsear.searo.who.int/handle/123456789/142055Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.enAnaplastic large cell lymphomaflow cytometryleukemic phaseAdolescentAntigens, CD30 --analysisAntigens, CD45 --analysisChildDisease ProgressionFemaleFlow CytometryHumansInterleukin-2 Receptor alpha Subunit --analysisLeukemia, Lymphoid --pathologyLeukocytes, Mononuclear --chemistryLymphoma, Large-Cell, Anaplastic --complicationsLymphoma, Large-Cell, Anaplastic --diagnosisLymphoma, Large-Cell, Anaplastic --pathologyMaleReceptor Protein-Tyrosine Kinases --metabolismLeukemia, Lymphoid --diagnosisArticle