Chandelia, SudhaJain, SarikaYadav, Dinesh KumarDubey, Nand Kishore2015-02-142015-02-142014-04Chandelia Sudha, Jain Sarika, Yadav Dinesh Kumar, Dubey Nand Kishore. Inferior vena cava thrombosis in a case of amoebic liver abscess: Is hypercomplementemia responsible for this rare entity. Indian Journal of Pathology & Microbiology. 2014 Apr-Jun 57 (2): 329-331.http://imsear.searo.who.int/handle/123456789/156046Among the liver abscesses, thrombosis of the inferior vena cava (IVC) has been reported mainly in amoebic liver abscess (ALA) caused by Entamoeba histolytica (E.H). It is an unusual complication especially in paediatric age group. Association of hypercomplementemia and IVC thrombosis has not been discussed previously. Published data suggest that E.H can activate the complement system and can cause hypercomplementemia. A very few studies suggest that complement activation and hypercomplementemia are associated with thrombus formation. We describe a paediatric case of ALA complicated by IVC thrombosis extending to the right atrium and discuss the possible role of hypercomplementemia in causation of IVC thrombosis in cases of ALA.enAmoebic liver abscesscomplement proteins 3 and 4inferior vena cava thrombosisArticle