Senior, RBatabyal, S KDutta, R NGuha, SDutta, SBhattacharji, T DKundu, S CMaity, A KKar, C C1990-01-012009-05-271990-01-012009-05-271990-01-01Senior R, Batabyal SK, Dutta RN, Guha S, Dutta S, Bhattacharji TD, Kundu SC, Maity AK, Kar CC. An echo-cardiographic (M-mode & 2D) analysis of thalassaemia major. Indian Heart Journal. 1990 Jan-Feb; 42(1): 73-6http://imsear.searo.who.int/handle/123456789/427325 cases of thalassaemia major were studied by 2D and M-mode echocardiography. A significantly increased (p less than 0.001) mean value (100.8 +/- 27.37 msec, range 80 to 140 msec) of A2-E (early relaxation period) interval on M-mode was observed in thalassemia in comparison to mean level (82.6 +/- 5.7, range 60 to 100 msec) of control population. No significant differences were noted in FS % (fractional shortening) and EF% (ejection fraction) when compared to corresponding normal values respectively. Mean serum iron concentration (142.2 +/- 29.1 micrograms/dl, range 102 to 192 micrograms/dl) was significantly higher in thalassaemia as compared to normal population (mean 106.3 +/- 11.4 micrograms/dl, range 75 to 120 micrograms/dl). There was also a direct correlation between serum iron concentration and A2-E interval. 11 patients (44%) showed abnormal A2-E interval but only 3 patients (12%) showed abnormal percentage of FS and EF. It is therefore concluded that A2-E interval will help to detect early left ventricular dysfunction much before overt and irreversible heart failure becomes manifest and which will also help to optimise transfusion and chelation therapy.engAdolescentChildEchocardiographyFemaleHemoglobins --analysisHumansMaleThalassemia --physiopathologyJournal Article